Dr. Blair Sampson, USDA-ARS, gave a presentation on important insect pests of muscadine grapes. Although muscadines don’t have too many serious pests there are a few to be concerned with. See more details below.
Grape Flea Beetle — The grape flea beetle is usually a sporadic pest during the early growing season, but has the capability to do significant economic damage if left unchecked. For photos of the insect and more detailed information go here: http://www.extension.org/pages/31592/grape-flea-beetle-altica-chalybea
Grape Root Borer — This insect mimics a wasp. Grape root borer has a single yellow stripe across the back and a dark forewing and clear hindwing. The larva tunnels into the grape root and causes the significant damage. For photos and more detailed information go here: http://www.extension.org/pages/54593/grape-root-borer and here http://www.extension.org/pages/63244/the-grape-root-borer-in-tennessee
Spotted Wing Drosophila (SWD) — SWD is known to infest many plant species worldwide and has the greatest potential to severely damage thin-skinned berry crops, but muscadines are also vulnerable. This is a new pest in Mississippi, so monitoring for its presence should be part of any IPM program. For more information on SWD, see the extensive article in the Mississippi Vaccinium Journal 1(3):3-9. (http://msucares.com/newsletters/vaccinium/2012/msvj_1_3.pdf)